Answer to Question #179472 in Biochemistry for Kim

Question

What factors influence the metabolic rate of citrate in the mitochondria?

Answer 1

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metabolic rate of citrate

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The estimated mean total citrate administered via blood and blood products was calculated as 43.2±34.19 mg/kilogram/day.

$\bull$ In non-massive and frequent blood transfusions, the elevated carbon dioxide output has been shown to occur.

$\bull$ Due to citrate metabolism causes intracellular acidosis.

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Citrate Provides a Bridge Between Carbohydrate and Fatty Acid

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Citrate metabolism plays an important role in many food fermentations involving lactic acid bacteria.

$\bull$ Since citrate is a. highly oxidized substrate, no reducing equivalents are produced during its degradation,

$\bull$ resulting in the formation of metabolic end products other than lactic acid.

$\bull$ Citrate metabolism in resting cells of Lactococcus lactis IL1403(pFL3) results in the formation of two end products from the intermediate pyruvate, acetoin and acetate 

$\bull$ Pyruvate is formed from citrate following uptake by the transporter CitP through the subsequent actions of citrate lyase and oxaloacetate decarboxylase.