Answer to Question #198367 in Biochemistry for aqsa urooj

Question

Almost no metabolic reaction is able to occur without the help of an enzyme. Explain how the structure of an allosteric enzyme and substrate function to control a metabolic pathway. Include a specific example in your answer. 

Answer 1

• In noncompetitive inhibition (also known as allosteric inhibition), an inhibitor binds to an allosteric site; the substrate can still bind to the enzyme, but the enzyme is no longer in optimal position to catalyze the reaction.
• Allosteric inhibitors induce a conformational change that changes the shape of the active site and reduces the affinity of the enzyme’s active site for its substrate.