Answer to Question #273476 in Biochemistry for nk123

Question

What is the connection between glucagon and urea cycle?

Answer 1

Glucagon receptor signalling increases urea cycle activity by activating the cAMP-protein kinase A (PKA)-cAMP response element-binding (CREB) protein-pathway, resulting in transcription of urea cycle enzymes and amino acid transporters, the latter serving to increase substrate availability