A monomeric enzyme catalyzing a reaction located somewhere in the middle of a metabolic pathway has mutated so that the value of Km for its only substrate has doubled. Under constant other conditions, how should the concentration of the substrate of this enzyme be changed so that the rate of metabolic flow through this metabolic chain remains constant? (select one)
a. to reduce it three times
b. to reduce it exactly in half
c. to increase it exactly twice
d. to increase it between one and a half times
e. to increase it more than double
Option( C) to increase it exactly twice
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