Answer to Question #183741 in Cell Biology for Areeba

Question

What is the importance of signal sequence in protein import in the ER? Detail answer

Answer 1

Signal sequences play a key role during the first steps of the intracellular transport of G protein-coupled receptors (GPCRs). They are involved in targeting of the nascent chains to the membrane of the endoplasmic reticulum (ER) and initiate integration of the newly synthesized receptors into this compartment.