Answer to Question #210559 in Genetics for kavya

Question

You have just discovered a drug that is able to inhibit DNA ligase.

You add this DNA ligase inhibitor to a cell population and let these cells divide. You then isolate the DNA from the daughter cells and analyze it. Before the analysis, the DNA molecules were denatured (the DNA strands were separated into single strands). What do you expect to see?

Answer 1

Some very long DNA molecules and a collection of short DNA molecules will be seen because, When DNA ligase is inhibited it differently effects the synthesis from the leading and lagging strands.