Answer to Question #105820 in Human Anatomy and Physiology for Brittney

Question

(ii) Some diuretics used in medicine inhibits the reabsorption of chloride ions in the Loop of Henle. Explain how this would lead to an increase in urine production.
[ 2 marks]

Answer 1

Loop diuretics inhibit the Na/K/2Cl transporter in the thick ascending loop of Henle this results into decreased water reabsorption into blood. There are two reasons causing it:

1)Loop diuretics stimulate the release of renin, which increases glomerular filtration rate (GFR) leading to an increased amount of primary urine;

2)Because of increased amount of electrolytes in the primary urine, reabsorption of water in the Loop of Henle is decreased, leading to higher volume of the secondary urine.