Ground substance is a clear, colorless, viscous fluid that fills the space between the cells and fibers. It is composed of proteoglycans and cell adhesion proteins that allow the connective tissue to act as glue for the cells to attach to the matrix.
A fibroblast is a type of cell that is responsible for making the extracellular matrix and collagen. Together, this extracellular matrix and collagen form the structural framework of tissues in animals and plays an important role in tissue repair. Fibroblasts are the main connective tissue cells present in the body.
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