Answer to Question #63937 in Human Anatomy and Physiology for alexis

Question

Adult onset diabetes, diabetes type 2, can best be described using which of the following concepts?

Constantly high blood sugar leads to glucagon release. Glucagon is an antagonist to insulin, leading to a decrease in insulin.
Constantly high blood sugar leads to the release of glucagon. Glucagon causes gluconeogenesis, which makes blood sugar higher.
Constantly high blood sugar leads to high insulin release. High amounts of insulin lead to down-regulation of insulin receptors.
Constantly high blood sugar leads to high insulin release. High levels of insulin cause up-regulation of insulin receptors.

Answer 1

Constantly high blood sugar leads to high insulin release. High amounts of insulin lead to down-regulation of insulin receptors.