Answer to Question #187836 in Molecular Biology for FAIZAN KHAN

Question

5. Familial breast cancer and ovarian cancer (BC) are diagnosed in almost every 10th woman in Europe. Approximately 5-10% of breast cancer is hereditary. Mapped and identified two genes - oncosuppressor –BRCA –1 and BRCA – 2, mutations in which are the cause of familial breast cancer and ovaries. In which human chromosome are the BRCA – 1 and BRCA – 2 genes localized?

    - Complete the quest with:

·               · Online Mendelian Inheritance in Man (OMIM)

·        Human Genome Mutation Database (HGMD)

Answer 1

BRCA1 genes are located on chromosome number 17 while BRCA2 genes are located on chromosome 13.