What is “mismatched” in the process of mismatch repair?
What is “loss of heterozygosity,” and how is this phenomenon related to the progression of some types of cancer?
What is apoptosis, and what role does it play in preserving the integrity of the genome of a multi- cellular organism?
What is a cell-cycle checkpoint? Which check- points are emphasized in this chapter, and what does each “check” for?
Proteins are dynamic macromolecules. To study proteins a scientist needs to understand their chemical and physical properties. You are a scientist working in an analytical laboratory, your job description is to analyse proteins. A crude sample containing a protein is to be analysed. Discuss all steps and techniques that can be employed in order to isolate, characterise, and determine its amino acid sequence.
Discuss the contribution by scientist that led to the development of central dogma. Further explain how genetic information is expressed in proteins.
discuss the formation of a peptide bond at ph 7. in your answer describe the.basic structure of this molecule including covalent bonds linking the amino acids , ionised end groups partial double bond character of the peptide bond. also include in your answer general features.side chains and the importance of associated non covalent bond interactions in protein structure
What would happen if an electrolyte solution was not used to make the gel for gel electrophoresis?
The following fragments were obtained after digestion of a sequence using restriction enzymes: 5.3 kb, 2.1 kb, 6.8 kb, 3.6 kb, 1.1 kb, 2.2 kb. Order the fragments, moving from the fastest migration to the slowest migration on a gel. Which two fragments may be difficult to isolate on a gel? Why? Sketch the resulting gel after running the fragments on it. Assume that the fragments were all run in one lane. Label the positions of the positive and negative electrodes.
List the fundamental properties shared by all cells. Describe the importance of each of these properties.